CAR-T 细胞疗法是癌症治疗领域的一项重大突破，也是基因工程细胞作为治疗手段的有力证明。除了已获批准用于白血病等血液类癌症治疗以外，CAR-T 细胞疗法还在实体瘤、自身免疫疾病以及组织再生方面也展现出巨大潜力。 然而，大量临床试验显示，CAR-T 细胞 ...

本综述系统回顾了CRISPR-Cas技术从原核免疫机制发展为精准基因组工程多功能工具的演进历程。通过对比传统方法（如RNAi、ZFNs、TALENs），凸显其靶向特异性、多重编辑和设计便捷性优势，并深入探讨了各类Cas酶（如Cas9、dCas9、Cas12a、Cas13）的机制创新及其在疾病 ...

麻省总医院布莱根分校（Mass General Brigham）和麻省理工学院-哈佛大学布罗德研究所（Broad Institute）的研究人员发现了可以提高嵌合抗原受体（CAR）-T细胞疗法疗效的基因修饰。CAR-T细胞疗法是一种利用经过修饰的患者T细胞靶向癌症的免疫疗法。该研究利用CRISPR ...

The gene-editing technique known as CRISPR is promising to revolutionize medicine. Some researchers are trying to help make it available for people with very rare genetic disorders. A gene-editing ...

When the genome-editing tool CRISPR is thought of as a potential medicine, the targets that first come to mind are diseases like sickle cell or other conditions caused by particular mutations. Use ...

Banas is associate director of research at the Gene Editing Institute at ChristianaCare, where Kmiec is founder and executive director. The medical promise of CRISPR gene editing can be seen most ...

The practice of genetic modification is as old as humanity. For thousands of years, humans have bred crops, livestock and even pets that possess desirable traits. This selective process, which alters ...

Researchers are further improving CRISPR's versatility to engineer new grasses and yeasts for biochemical production. CRISPR/Cas systems have undergone tremendous advancement in the past decade. These ...

CRISPR, the gene-editing technology that has revolutionized biological research, is finally available as a medical treatment with regulatory approval. On December 8 the U.S. Food and Drug ...

CRISPR Therapeutics (CRSP) just announced that its SyNTase gene editing technology will be featured in an oral presentation at the ESGCT 2025 Congress. This marks the first major public unveiling of ...